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Broadly effective metabolic and immune recovery with C5 inhibition in CHAPLE disease

Özen, Ahmet; Kasap, Nurhan; Vujkovic-Cvijin, Ivan; Apps, Richard; Cheung, Foo; Karakoç Aydıner, Elif; Lenardo, Michael J. (Nature Research, 2020)

CHAPLE disease is a lethal syndrome caused by genetic loss of the complement regulatory protein CD55. Lenardo, Ozen and their colleagues report that blockade of C5 complement activation in a small cohort of pediatric ...