The relationship between oral cancer and cadmium: a review
Abstract
Cadmium (Cd) has been classifed as a type I carcinogen. Since it is ingested orally through food and tobacco use, Cd is likely
to be closely related to oral cancers. The relationship between cadmium and oral cancer was investigated using papers on
Pubmed and Web of Science. Thus a total of 11 studies from these databases were included in the review. Cd concentrations
were signifcantly higher in both the blood and hair of oral cancer patients than in controls. Additionally, it has been reported
that Cd increases the activity of reactive oxygen species. Tobacco plants contain varying levels of Cd. The presence of high
Cd concentrations in patients who use tobacco products and develop oral cancer is strong evidence that Cd is directly related
to oral cancer. While planning a study to determine the Cd concentrations in biological samples, it is advisable to examine
the methodologies of previous studies and to avoid technical defciencies. New cell line studies are required to explain the
relationship between Cd and autophagy-apoptosis.
Source
Molecular Biology ReportsIssue
49URI
https://link.springer.com/article/10.1007/s11033-021-07000-whttps://hdl.handle.net/20.500.12868/2510