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Melatonin affects the release of exosomes and tau-content in in vitro amyloid-beta toxicity model
(Churchill Livingstone, 2020)
Background: Recent studies have been revealed that oxidative damage is the main cause of aging and age-related neurodegenerative diseases like Alzheimer's disease (AD). Melatonin is secreted from the pineal gland and its ...
Effects of homocysteine and memantine on oxidative stress related TRP cation channels inin-vitromodel of Alzheimer's disease
(Taylor & Francis Ltd, 2020)
Memantine (MEM) has been used to treat patients with Alzheimer' disease though inhibition of reactive oxygen species (ROS), Ca(2+)entry and glutamate receptor. The Ca(2+)permeable TRPA1, TRPM2 and TRPV1 channels are activated ...
Specific alterations in the circulating levels of the SIRT1, TLR4, and IL7 proteins in patients with dementia
(Pergamon-Elsevier Science Ltd, 2018)
Sirtuins have gained considerable attention as epigenetic regulators for slowing aging and age-related disorders. The growing association between neurodegeneration and inflammation has led researchers to investigate ...