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Toplam kayıt 8, listelenen: 1-8
Polyethers isolated from the marine actinobacterium Streptomyces cacaoi inhibit autophagy and induce apoptosis in cancer cells
(Elsevier Ireland Ltd, 2019)
Polyether compounds, a large group of biologically active metabolites produced by Streptomyces species have been reported to show a variety of bioactivity such as antibacterial, antifungal, antiparasitic, antiviral, and ...
Ameliorative effects of pregabalin on LPS induced endothelial and cardiac toxicity
(Taylor & Francis Ltd, 2020)
We investigated the antioxidant, anti-inflammatory and anti-apoptotic effects of pregabalin (PREG) on lipopolysaccharide (LPS) induced sepsis related cardiotoxicity via NF-k beta pathways. We used 24 female Wistar albino ...
Clostridium botulinumneurotoxin A induces apoptosis and mitochondrial oxidative stress via activation of TRPM2 channel signaling pathway in neuroblastoma and glioblastoma tumor cells
(Taylor & Francis Ltd, 2020)
Background TheClostridium botulinumneurotoxin A (BTX) is a polypeptide produced by the bacteriumClostridium botulinum. In addition to the therapeutic actions of BTX against pain and neuromuscular disorders, it is acted as ...
Calorie restriction protects against apoptosis, mitochondrial oxidative stress and increased calcium signaling through inhibition of TRPV1 channel in the hippocampus and dorsal root ganglion of rats
(Springer/Plenum Publishers, 2018)
The TRPV1 channel is activated in neurons by capsaicin, oxidative stress, acidic pH and heat factors, and these factors are attenuated by the antioxidant role of calorie restriction (CR). Hence, we investigated the hypothesis ...
Agomelatine could prevent brain and cerebellum injury against LPS-induced neuroinflammation in rats
(Academic Press Ltd- Elsevier Science Ltd, 2020)
Sepsis, systemic hyper-inflammatory immune response, causes the increase of morbidity and mortality rates due to multi-organ diseases such as neurotoxicity. Lipopolysaccharide (LPS) induces inflammation, oxidative stress ...
Protective effects of N-acetyl cysteine against paclitaxel-induced cardiotoxicity through modulation of transient receptor potential melastatin 2 channels
(Gazi Univ, Fac Med, 2019)
Aim : In our study, we investigated the paclitaxel induced cardiotoxicity and alterations in Ca2+ influx, oxidative stress and apoptosis through transient receptor potential melastatin 2 (TRPM2) channels and modulator role ...
Apoptotic efficiency of capecitabine and 5-fluorouracil on human cancer cells through TRPV1 channels
(Natl Inst Science Communication-Niscair, 2020)
The expression of transient receptor potential protein channels increases intensively colon and breast cancer cells. We aimed to reveal the role of 5-fluorouracil (5FU) and capecitabine along with Transient Receptor Potential ...
Zoledronic Acid, Bevacizumab and Dexamethasone-induced Apoptosis, Mitochondrial Oxidative stress, and Calcium signaling are decreased in human Osteoblast-like cell line by Selenium treatment
(Humana Press Inc, 2018)
Increased intracellular free calcium ion (Ca2+) concentration induces excessive oxidative stress and apoptosis. Medical procedures such as zoledronic acid (Zol), bevacizumab (Bev), and dexamethasone (Dex) are usually used ...