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Toplam kayıt 8, listelenen: 1-8
Does maternal exposure to artificial food coloring additives increase oxidative stress in the skin of rats?
(Sage Publications Ltd, 2017)
Glutathione-S-transferase (GST) and cytochrome P450 family 1 subfamily A polypeptide 1 (CYP1A1) metabolize and detoxify carcinogens, drugs, environmental pollutants, and reactive oxygen species. Changes of GST expression ...
Ameliorative effects of pregabalin on LPS induced endothelial and cardiac toxicity
(Taylor & Francis Ltd, 2020)
We investigated the antioxidant, anti-inflammatory and anti-apoptotic effects of pregabalin (PREG) on lipopolysaccharide (LPS) induced sepsis related cardiotoxicity via NF-k beta pathways. We used 24 female Wistar albino ...
The impact of prophylactic lacosamide on LPS-induced neuroinflammation in aged rats
(Springer/Plenum Publishers, 2019)
Sepsis-induced central nervous system damage is called sepsis-associated encephalopathy (SAE). In addition to neuroinflammation, oxidative stress and apoptosis act in the development of SAE. In the current study, we evaluated ...
Synergic and comparative effect of 5-fluorouracil and leucoverin on breast and colon cancer cells through TRPM2 channels
(Comenius Univ, 2018)
OBJECTIVES: We aimed to reveal the role of 5-fluorouracil (5-FU) and Leucovorin (LV) along with transient receptor potential protein melastatin 2 (TRPM2) channels in breast and colon cancer cells during the treatment ...
The effect of melatonin on digoxin-induced cardiac damage in cardiomyocytes
(Comenius Univ, 2019)
OBJECTIVES: Digoxin is a cardiac glycoside which is widely used in cardiovascular medicine. Oxidative stress, as well as intracellular Ca2+ overload, plays an important role in digoxin toxicity. Transient receptor potential ...
Oxidative stress upregulates the transcription of genes involved in thiamine metabolism
(Tubitak Scientific & Technical Research Council Turkey, 2018)
Thiamine is a major vitamin that acts as a cofactor in energy metabolism in all organisms, as well as in lipid and amino acid metabolisms, and is associated with many diseases. It is known that glucose starvation decreases ...
Continuous erythropoietin receptor activator ameliorates diabetic kidney disease in rats
(Aves, 2020)
Objective: Diabetic kidney disease (DKD) is still a significant cause of morbidity in patients with diabetes. In this study, we examined the potential effects of continuous erythropoietin receptor activator (CERA) on ...
The effect of Resveratrol on sphingosine-1 and Oxidative/ Nitrosative stress in an experimental heart ischemia reperfusion model
(2022)
Objectives: Resveratrol (RSV) is a natural polyphenolic compound showing significant antioxidant effects. In this
study, we aimed to investigate the effects of resveratrol on the sphingosine-1-phosphate (S1P) and oxidative ...