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Ameliorative effects of pregabalin on LPS induced endothelial and cardiac toxicity
(Taylor & Francis Ltd, 2020)
We investigated the antioxidant, anti-inflammatory and anti-apoptotic effects of pregabalin (PREG) on lipopolysaccharide (LPS) induced sepsis related cardiotoxicity via NF-k beta pathways. We used 24 female Wistar albino ...
Clostridium botulinumneurotoxin A induces apoptosis and mitochondrial oxidative stress via activation of TRPM2 channel signaling pathway in neuroblastoma and glioblastoma tumor cells
(Taylor & Francis Ltd, 2020)
Background TheClostridium botulinumneurotoxin A (BTX) is a polypeptide produced by the bacteriumClostridium botulinum. In addition to the therapeutic actions of BTX against pain and neuromuscular disorders, it is acted as ...
Agomelatine could prevent brain and cerebellum injury against LPS-induced neuroinflammation in rats
(Academic Press Ltd- Elsevier Science Ltd, 2020)
Sepsis, systemic hyper-inflammatory immune response, causes the increase of morbidity and mortality rates due to multi-organ diseases such as neurotoxicity. Lipopolysaccharide (LPS) induces inflammation, oxidative stress ...
Apoptotic efficiency of capecitabine and 5-fluorouracil on human cancer cells through TRPV1 channels
(Natl Inst Science Communication-Niscair, 2020)
The expression of transient receptor potential protein channels increases intensively colon and breast cancer cells. We aimed to reveal the role of 5-fluorouracil (5FU) and capecitabine along with Transient Receptor Potential ...