Are Platelet-related Parameters Predictive of the Prognosis of Hodgkin’s Lymphoma?

Abstract

Objective: Hodgkin’s lymphoma has a good prognosis unless it has relapsed or become refractory. The predictive value of platelet (Plt)-related parameters, namely, mean Plt volume (MPV), plateletcrit (PCT), Plt distribution width, and Plt, is shown in some solid tumors and hematological malignancies, but it remains unknown in Hodgkin’s lymphoma. This study aimed to define their values and effects on staging and relapsing status in patients with Hodgkin’s lymphoma by comparing them with those in healthy subjects. Methods: Values of Plt-related parameters of 217 patients with Hodgkin’s lymphoma and 205 healthy individuals were documented and compared according to the disease stage and relapsing status. We defined the cutoff values for diagnosis, staging, and relapsing status of these parameters using the receiving operating characteristic curve analysis. Results: For diagnosis, the cutoff values of MPV, Plt, and PCT were 8.49 fL, 32,1000/mm³, and 0.31, respectively. For staging, the cutoff values of MPV and Plt were 9.5 fL and 12 fL, respectively. None of the parameters were associated with relapsing status. Conclusion: This is the first study evaluating Plt-related parameters in Hodgkin’s lymphoma. Further studies including survival analyses will clarify the effect of these parameters on Hodgkin’s lymphoma.