| dc.description.abstract | Objectives: The relationship between major depressive disorder (MDD) and, especially harm avoidance, self-directedness, and
cooperativeness has been determined based on Cloninger’s psychobiological personality model; there are not enough studies in
the literature on the role of the subdimensions. Therefore, the aim of this study was to compare the patients with MDD and healthy
controls in terms of temperament and character traits and especially subdimensions and thus to determine the role and predictive
value of temperament and character subdimensions in major depression patients.
Methods: The sample of this cross-sectional study consisted of 105 participants, 65 of whom were MDD patients, and 40 healthy
controls, who voluntarily agreed to participate in the study. Sociodemographic data form, temperament and character inventory,
and Hamilton depression rating scale were administered to the participants.
Results: Compared with healthy controls, patients with MDD had lower self-directedness (p<0.001), cooperativeness (p=0.017),
persistence (p<0.001), self-transcendence (p=0.001), and higher harm avoidance (p<0.001) scores. While there was no significant
difference in novelty seeking (p=0.774); it was determined that MDD patients got higher scores in “Impulsiveness” (p=0.013) and
lower scores in “Exploratory excitability” (p=0.001) subscales. Reward dependence has been identified as the only personality trait
that there was no significant difference between major depression patients and healthy controls (p=0.511). As a result of the logis tic regression analysis performed to determine the predictors of temperament and character subdimensions in major depression
patients, only three temperament and character traits “Fatigability, Purposefulness, and Spiritual Acceptance” were determined as
significant predictors (p<0.001). Fatigability was determined to be a serious risk factor, increasing the probability of MDD 3.6 times
(p<0.001); purposefulness and spiritual acceptance were found to be protective personality traits that together reduced the prob ability of MDD by 0.8 times (p<0.001).
Conclusion: This study shows that the risk of developing MDD is increased in individuals with low self-directedness, cooperative ness, persistence, and self-transcendence profiles, and whereas with prominent Harm avoidance personality traits. Therapeutic in terventions, especially considering the temperament and character traits of “Fatigability, Purposefulness, and Spiritual Acceptance”
determined in our study, may contribute positively to MDD treatment. | en_US |
