Ara
Toplam kayıt 16, listelenen: 1-10
Effect of astaxanthin in imatinib mesylate-induced cardiotoxicity
(Alanya Alaaddin Keykubat Üniversitesi, 2020)
Aim: Imatinib mesylate is a tyrosine kinase inhibitor and is approved as a standard first-line therapy of chronic myeloid leukemia. Oxidative stress, as well as intracellular calcium overload and mitochondrial dysfunction, ...
Synergic and comparative effect of 5-fluorouracil and leucoverin on breast and colon cancer cells through TRPM2 channels
(Comenius Univ, 2018)
OBJECTIVES: We aimed to reveal the role of 5-fluorouracil (5-FU) and Leucovorin (LV) along with transient receptor potential protein melastatin 2 (TRPM2) channels in breast and colon cancer cells during the treatment ...
Selenium enhances TRPA1 channel-mediated activity of temozolomide in SH-SY5Y neuroblastoma cells
(Springer, 2020)
Purpose Neuroblastoma is a malignant solid tumor that originates from the sympathetic nervous system in early childhood. Temozolomide is used for treatment in high-risk groups with low treatment response of neuroblastomas. ...
The effect of melatonin on digoxin-induced cardiac damage in cardiomyocytes
(Comenius Univ, 2019)
OBJECTIVES: Digoxin is a cardiac glycoside which is widely used in cardiovascular medicine. Oxidative stress, as well as intracellular Ca2+ overload, plays an important role in digoxin toxicity. Transient receptor potential ...
The role of selenium in bevacizumab induced cardiotoxicity
(Comenius Univ, 2019)
OBJECTIVE: We investigated the role of selenium in bevacizumab induced cardiotoxicity and involvement of transient receptor potential vanilloid 1 (TRPV1) channels in cardiomyocytes. MATERIALS AND METHODS: All cells (Human ...
Selenium enhances TRPA1 channel-mediated activity of temozolomide in SH-SY5Y neuroblastoma cells (vol 21, pg 541, 2020)
(Springer, 2020)
[No abstract available]
Effects of homocysteine and memantine on oxidative stress related TRP cation channels inin-vitromodel of Alzheimer's disease
(Taylor & Francis Ltd, 2020)
Memantine (MEM) has been used to treat patients with Alzheimer' disease though inhibition of reactive oxygen species (ROS), Ca(2+)entry and glutamate receptor. The Ca(2+)permeable TRPA1, TRPM2 and TRPV1 channels are activated ...
LLLT enhance cyclophosphamide induced TRPM2 channel activation in human colon cancer cells
(Comenius Univ, 2020)
AIM: Transient receptor potential (TRP) channels expression is enhanced significantly in colon cancer cells and Low Lever Laser Treatment (LLLT), is known to have effects and is used clinically in the treatment ofmany ...
Protective effects of N-acetyl cysteine against paclitaxel-induced cardiotoxicity through modulation of transient receptor potential melastatin 2 channels
(Gazi Univ, Fac Med, 2019)
Aim : In our study, we investigated the paclitaxel induced cardiotoxicity and alterations in Ca2+ influx, oxidative stress and apoptosis through transient receptor potential melastatin 2 (TRPM2) channels and modulator role ...
The effects of carvacrol on oxidative stress parameters and adoptosis process via TRPA1 channels in neuroblastoma cells
(Polskie Towarzystwo Farmaceutyczne, 2019)
Objectives: This study is a preliminary study to investigate the effects of carvacrol (CRV) obtained from thyme on the apoptosis process in neuroblastoma cells. Methods: In this study, seven groups were designed as control, ...