Araştırma Çıktıları (TR Dizin / Web of Science / Scopus / PubMed)Research Output (TR Dizin / Web of Science / Scopus ve PubMed)https://hdl.handle.net/20.500.12868/12024-03-29T07:17:42Z2024-03-29T07:17:42ZOcular surface microbiota changes after external dacryocystorhinostomy: a “chicken or egg” problemAslan, FatihDoğan, BoraŞahin, Canerhttps://hdl.handle.net/20.500.12868/24512023-12-01T07:47:15Z2020-01-01T00:00:00ZOcular surface microbiota changes after external dacryocystorhinostomy: a “chicken or egg” problem
Aslan, Fatih; Doğan, Bora; Şahin, Caner
Objective: The aim of this study was to evaluate changes in the ocular surface and nasal microbiota after external dacryocystorhinostomy (DCR) in patients with unilateral nasolacrimal duct obstruction (NLDO). Methods: This prospective study included 68 eyes of 34 patients. Prior to external DCR, nasal and conjunctival smears were obtained from the affected eye and healthy contralateral eye. Results: Ocular surface cultures were positive in 19 (55.9%) of the NLDO eyes and 4 (11.8%) of the healthy eyes (p[removed]
2020-01-01T00:00:00ZIs spinal anesthesia an alternative and feasible method for proximal ureteral stone treatment?Topaktaş, RamazanAltın, SelçukAydın, CemilAkkoç, AliÜrkmez, AhmetAydın, Zeynep Banuhttps://hdl.handle.net/20.500.12868/24502023-11-30T06:55:52Z2020-01-01T00:00:00ZIs spinal anesthesia an alternative and feasible method for proximal ureteral stone treatment?
Topaktaş, Ramazan; Altın, Selçuk; Aydın, Cemil; Akkoç, Ali; Ürkmez, Ahmet; Aydın, Zeynep Banu
Introduction We investigated the clinical, operational, and pain parameters of patients who underwent
semirigid ureterorenoscopy (sURS) under spinal anesthesia (SA) and general anesthesia (GA) for proximal
ureter stones.
Material and methods Patients treated with sURS after diagnosis of proximal ureter stones between
January 2014 and May 2017 were reviewed retrospectively. The patients were divided into two groups
(the SA group and the GA group) based on the type of anesthesia used. Perioperative variables and
operation results were evaluated and compared. Success was defined as the patient being stone-free as
observed on low-dose non-contrast computed tomography performed in the first month postoperatively.
Results The SA and GA groups had 40 and 32 patients, respectively. There were no statistically significant
differences between the groups in terms of age (p = 0.593), gender (p = 0.910), average stone size
(p = 0.056), side (p = 0.958), or density (p = 0.337). Based on the Clavien classification system, complication rates between the two groups were similar. The postoperative visual pain scale in the SA group was
statistically significantly lower (p <0.05) than in the GA group. Success rates in the SA and GA groups
were found to be 90% (36/40) and 93.7% (30/32), respectively, with no significant difference between
the groups (p = 0.819).
Conclusions Ureterorenoscopy, which is performed for proximal ureter stone treatment in adult patients, is
a reliable surgical method that can be performed under both SA and GA. SA offers the advantage of reduced
postoperative pain as compared to GA.
2020-01-01T00:00:00ZThe effect of aging and exercise training on carbon monoxide relaxation response in thoracic aorta and gastrocnemius feed arteryhttps://hdl.handle.net/20.500.12868/24492023-11-30T06:55:14Z2020-01-01T00:00:00ZThe effect of aging and exercise training on carbon monoxide relaxation response in thoracic aorta and gastrocnemius feed artery
Amaç: Bu çalışmanın amacı yaşlanma ve yüzme
egzersizine bağlı olarak sıçanların torasik aortasında ve
gastroknemius iletim arterinde karbon monoksit (CO)’e
verilen damar yanıtlarının değişip değişmediğini test
etmektir.
Yöntem: Çalışmamızda 4 aylık genç ve 24 aylık yaşlı
Wistar dişi sıçanlar kullanıldı. Sıçanlar rastgele gençsedanter (GS), genç-egzersiz (GE), yaşlı-sedanter (YS)
ve yaşlı-egzersiz (YE) olmak üzere dört gruba ayrıldı.
Egzersiz gruplarına 8 hafta süresince haftada 5 gün,
günde 1 saat yüzme egzersizi yaptırıldı. Sıçanlardan izole
edilen torasik aorta halkaları organ banyosu düzeneğinde,
gastroknemius iletim arteri ise telli miyograf düzeneğinde
çalışıldı. Aort ve gastroknemius iletim arteri halkalarının
fenilefrin (PE) kasılma yanıtları hemoksijenaz inhibitörü
chromium mesoporphyrin inkübasyonu öncesi ve
sonrasında kaydedilerek endojen olarak üretilen CO’in
vasküler tonusa katkısı değerlendirildi. CO donörü (CORM;
carbon - monoxide - releasing - molecule) kullanılarak
ekzojen gevşeme yanıtları değerlendirildi.
Bulgular: CrMP inkübasyonu öncesinde ve
sonrasında PE doz yanıt eğrilerinde hem aortada hem
de gastroknemius iletim arterinde gruplar arasında fark yoktu. CrMP inkübasyonu sonrasında alınan maksimum
PE kasılma yanıtları aort halkalarında GE, YS ve YE
gruplarında anlamlı olarak daha yüksekti (p<0,05),
gastroknemius iletim arterlerinde ise sadece GS ve GE
gruplarında anlamlı olarak yüksekti (p<0,01). CORM’a
verilen maksimum gevşeme yanıtlarında gastroknemius
iletim arterinde gruplar arasında fark yoktu. Aorta
halkalarında ise maksimum CORM gevşeme yanıtları yaşlı
gruplarda anlamlı olarak daha düşüktü (p<0,05).
Sonuç: Çalışmanın sonuçları; gastroknemius iletim
arterinde CO yanıtlarına egzersiz ve yaşlanmanın etkisi
olmadığını, Aorta halkalarında ise CO gevşeme yanıtının
yaşlanmayla birlikte azaldığını ve egzersizin CO gevşeme
yanıtını hem yaşlı hem de genç sıçanlarda arttırıcı bir
katkısının olmadığını göstermektedir.; Objective: The purpose of this study is to observe
any aging and swimming exercise associated changes
in the rat thoracic aorta and gastrocinemius feed
artery.
Methods: 4-month and 24-month old female rats
were used and divided into four following groups:
sedentary young, trained young, sedentary old, and
trained old. Swimming exercise was performed for
8 weeks (60 min/day, 5 days/week). Thoracic Aorta
and gastrocinemius feed artery isolated from the rats.
Thoracic Aorta rings were mounted on organ bath
and gastrocinemius feed arteries were mounted on
wire myograph. Contraction responses of all vessel
rings in presence and absence of HO inhibitor (CrMP)
were recorded as an endogenous CO contribution to
vascular tonus. The effect of exogenous CO relaxation
response were assesed by CO releasing molecule
(CORM).
Results: Phenylephrine dose- response curves with
or without CrMP were smilar in all groups both aortic
rings and gastrocnemius feed artery. The maximum PE
contraction responses obtained after CrMP incubation
were significantly higher in the GE, YS and YE groups (p <0.05) in the aortic rings, and only significantly
higher in the GS and GE groups in the gastrocnemius
feed arteries (p <0,01). There was no differences in the
maximum vasodilatation response of CORM reported
for all groups in gastrocnemius feed artery. However,
in the old groups CORM Emax values were established
significantly lower than that the young groups in the
aortic rings (p<0,05).
Conclusion: As a results of this study; exercise
and aging have no effect on CO responses in the
gastrocnemius feed artery. But the CO relaxation
response is decreased by aging in the thoracic aorta of
elderly rats and exercise does not have an enhancing
contribution for CO relaxation response in both old and
young rats.
2020-01-01T00:00:00ZCarbon monoxide contributes to the regulation of vascular tonus in renal resistance arteries in spontaneously hypertensive ratsKoçer, GünnurNasırcılar, SeherBasralı, FilizKuru, OktayŞentürk, Ümit Kemalhttps://hdl.handle.net/20.500.12868/24482023-11-30T06:55:06Z2020-01-01T00:00:00ZCarbon monoxide contributes to the regulation of vascular tonus in renal resistance arteries in spontaneously hypertensive rats
Koçer, Günnur; Nasırcılar, Seher; Basralı, Filiz; Kuru, Oktay; Şentürk, Ümit Kemal
Objective: Carbon monoxide (CO), an end product of heme oxygenase (HO) involved in the regulation of vascular tone, may show a compensatory effect in the course of hypertension. This study aimed to assess the effects of the HO/CO system on the vascular tone of renal resistance arteries in spontaneously hypertensive rats (SHRs). Methods: The contribution of endogenous CO to vascular tone in renal resistance arteries was evaluated by the phenylephrine (Phe) contraction response with or without an HO inhibitor. The effect of the exogenous CO relaxation response was assessed by a CO releasing molecule (CORM). The mechanism of the CO relaxation effect was evaluated by a guanylate cyclase inhibitor, ODQ, or a potassium channel blocker, TEA. HO-1 and HO-2 enzyme protein expressions in renal resistance arteries were determined by Western blot analysis. Results: Phe-induced constriction responses were higher in renal resistance arteries of SHRs compared to control animals. The extent of the same type of constriction was even higher in the SHR group after inhibition of CO production. Relaxation responses to a CO donor, CORM, were greater in the SHR group versus the control group. TEA, but not ODQ, suppressed CORM responses in both groups. HO-2 protein expression patterns were not different between the groups, while HO-1 expression was remarkably higher in SHRs when compared to that in control rats. Conclusion: Consequently, our results revealed a CO-based compensatory effect in SHRs by the induction of CO production and an increase in its bioavailability.
2020-01-01T00:00:00Z