Yazar "Özşimşek, Ahmet" için listeleme
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Alzheimer Hastalığının Önlenmesi ve Tedavisinde Melatoninin TRPA1 Kanalları Üzerinden Potansiyel Etkileri
Özşimşek, Ahmet; Övey, İshak Suat (2022)Amaç: Alzheimer hastalığı (AH) demansın en yaygın nedenidir ve ilerleyici bir nörodejeneratif hastalık olarak tanımlanır. AH ilerleyici bozukluğunun ana klinik özellikleri öğrenme ve hafıza kaybıdır. Çeşitli çalışmalar ... -
Clostridium botulinumneurotoxin A induces apoptosis and mitochondrial oxidative stress via activation of TRPM2 channel signaling pathway in neuroblastoma and glioblastoma tumor cells
Akpınar, Orhan; Özşimşek, Ahmet; Güzel, Mustafa; Nazıroğlu, Mustafa (Taylor & Francis Ltd, 2020)Background TheClostridium botulinumneurotoxin A (BTX) is a polypeptide produced by the bacteriumClostridium botulinum. In addition to the therapeutic actions of BTX against pain and neuromuscular disorders, it is acted as ... -
Combined metabolic activators improve cognitive functions in Alzheimer’s disease patients: a randomised, double-blinded, placebo-controlled phase-II trial
Yuluğ, Burak; Altay, Özlem; Li, Xiangyu; Hanoğlu, Lütfü; Çankaya, Şeyda; Lam, Simon; Velioğlu, Halil Aziz; Yang, Hong; Coşkun, Ebru; İdil, Ezgi; Nogaylar, Rahim; Özşimşek, Ahmet; Bayram, Cemil; Bolat, İsmail; Öner, Sena; Tozlu, Özlem Özdemir; Arslan, Mehmet Enes; Hacımüftüoğlu, Ahmet; Yıldırım, Serkan; Arif, Muhammad; Shoaie, Saeed; Zhang, Cheng; Nielsen, Jens; Turkez, Hasan; Boren, Jan; Uhlen, Mathias; Mardinoğlu, Adil (2023)Abstract Background Alzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administered combined metabolic activators (CMA) to the AD rat model ... -
Investigation of the Antiepileptics on Levels of Vitamin D and Calcium
Yuluğ, Burak; Özşimşek, Ahmet (2022)Aim: We investigated the connection between D vitamin and factors such as the type of antiepileptic agent, patient age and gender. Methods: This retrospective case-control study enrolled a total of 301 participants, ... -
The Relationship Between Serum 25-hydroxyvitamin D and Calcium Levels and Idiopathic Benign Paroxysmal Positional Vertigo
Özşimşek, Ahmet; Karaçay, Ertan (2022)Aim: We aimed to compare 25-hydroxy vitamin D (25-OH vitamin D) and Ca2+ levels of patients admitted to our clinic with the complaint of dizziness and diagnosed with idiopathic benign paroxysmal positional vertigo (BPPV) ... -
The relationship between the type of parkinson's disease and entrapment neuropathy in the upper extremities
Objective: Parkinson's disease (PD) is one of the common neurodegenerative disorders in the community. Compressive neuropathy (CN) is one of the conditions that negatively affect workforce and decreases the quality of life. ... -
Topological network mechanisms of clinical response to antidepressant treatment in drug-naive major depressive disorder
Uykur, Abdullah Burak; Yıldız, Sultan; Velioğlu, Halil Aziz; Özşimşek, Ahmet; Öktem, Ece Özdemir; Bayraktaroğlu, Zübeyir; Ergün, Tarkan; Lakadamyalı, Hatice; Hanoğlu, Lütfi; Hanoğlu, Lütfi; Çankaya, Şeyda; Saatçi, Özlem; Yuluğ, Burak (Churchill Livingstone, 2021)Aim: There is rapidly increasing evidence that remission of MDD is associated with substantial changes in functional brain connectivity. These New data have provided a holistic view on the mechanism of antidepressants on ...
